4:00 – 5:00 pm

Category: Biomed

Mapping the Human Body at Single-Cell Resolution: Developing the Human Reference Atlas

The Human BioMolecular Atlas Program (HuBMAP) aims to create a computable, open-source map of the human body at single-cell resolution. The resulting Human Reference Atlas (HRA) will map the human body from the whole body level to the level of the individual cell, redefining our understanding of the structure and interconnectedness of cells in the human body.Building upon technologies that allow scientists to read genetic code, tag genes, and analyze biomarkers and individual proteins at the cellular level, the HuBMAP portal (https://portal.hubmapconsortium.org) makes vast amounts of data searchable and supports interactive exploration of the different organs (https://portal.hubmapconsortium.org/ccf-eui). Potential applications include analysis of disease progression and treatment targets at the tissue and cellular levels; massive data collection for systemic and computational biology calculations; and a tremendous teaching tool that spans many biological and medical fields. Several data visualization tools are being developed in conjunction with the Human Reference Atlas, allowing for access to and interpretation of a wide range of tissue datasets and assay types. These tools can map and analyze multi-scale tissue samples from a wide range of expert contributors, and provide vitally accurate, beautiful open-source data visualizations. Funded by the NIH, this project is a multi-disciplinary research effort contributed to by over 350 experts in more than 50 institutions. More information can be found at https://hubmapconsortium.org.ReferencesSnyder MP, Greenleaf WJ, Ahadi S, Nevins SA, Lee H, Esplin E, et al. The human body at cellular resolution: the NIH Human Biomolecular Atlas Program. Nature 2019; 574:187-92. Börner K, Teichmann SA, Quardokus EM, Gee JC, Browne K, Osumi-Sutherland D, et al. Anatomical structures, cell types and biomarkers of the Human Reference Atlas. Nat Cell Biol 2021; 23:1117-28. https://doi.org/10.1038/s41556-021-00788-6.

Session Takeaways:

  1. After participating in this session, attendees should be able to access and explore the HuBMAP data portal, available at https://portal.hubmapconsortium.org.
  2. After participating in this session, attendees should be able to navigate the open-source Exploration User Interface.
  3. After participating in this session, attendees should be able to locate the open-source project repository on Github and further explore the HuBMAP project, available at https://github.com/hubmapconsortium.
  4. After participating in this session, attendees will be able to productively use the Design Style Guide and Standard Operating Procedures to create organs that can become part of the HRA.
Rachel Bajema

Rachel Bajema

Medical Illustrator, Cyberinfrastructure for Network Science Center, Indiana University

Rachel Bajema is a medical illustrator and animator working with Indiana University’s Cyberinfrastructure for Network Science Center in the Luddy School of Informatics, Computing, and Engineering. Rachel also runs Bajema Studios, LLC, providing medical illustration/animation work and art direction services. She is a graduate of UIC’s Biomedical Visualization program.

Heidi Schlehlein

Heidi Schlehlein

Medical Illustrator, Cyberinfrastructure for Network Science Center, Indiana University

Heidi Schlehlein is a medical illustrator and animator working with Indiana University’s Cyberinfrastructure for Network Science Center in the Luddy School of Informatics, Computing, and Engineering. Heidi runs SciSculpt, providing 3D printed medical models for researchers and pharmaceutical companies. She is a graduate of UIC’s Biomedical Visualization program.