2022 AMI Online Salon

The Role of Tissue-Factor Bearing Extracellular Vesicles in Cancer-Associated Thrombosis

Project Detail

  • Entrant Name:  Sydney Agger
  • Other Contributors:  Ana Beiriger
    Client:  Robert Flaumenhaft, MD, PhD and Jeffery Zwicker, MD, Harvard Medical School, Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center
  • Copyright:  Sydney Agger and Ana Beiriger, 2022
  • Medium/software used: Pixologic Zbrush, Autodesk 3D Studio Max, VRay, tyFlow, RCSB Protein Data Bank, Visual Molecular Dynamics, Red Giant Universe, Adobe Illustrator, Adobe After Effects, and Adobe Audition
  • Final presentation format: Animation for website and presentations
  • Primary Audience: Graduate Students and Researchers

Project Description

Thrombosis is a common complication and cause of death in patients with late stage cancer, accounting for up to 10% of cancer-related deaths in patients undergoing outpatient chemotherapy. However, the mechanisms underlying cancer-associated thrombosis are not well understood. Recent work by researchers at Harvard University has shown that cellular stress in pancreatic cancer cells causes increased vesicular trafficking of the procoagulant protein Tissue Factor (TF). Release of TF-bearing extracellular vesicles into the circulation can cause cancer-associated thrombosis even at sites distant to the primary tumor. This discovery is necessary for understanding the cause of thrombosis in cancer and is a critical piece of information for the development of therapies to prevent thrombosis-related deaths. This 3D animation aims to introduce the key player in this research, TF-bearing extracellular vesicles, and describe the series of events linking cancer progression to thrombosis.