2022 AMI Online Salon

The Progression of Nonalcoholic Steatohepatitis in the Liver

Project Details

  • Entrant Name:  Sarah Scull
  • Client: Radius Digital Science/Allergan
  • Copyright: Allergan, 2019
  • Medium/software used: Digital Sculpted/3D printed/Molded/Decorated
  • Final presentation format: Physical anatomical model on base
  • Primary Audience: Patient/Clinical trial candidates

Project Description

Nonalcoholic steatohepatitis (NASH) is inflammation in the liver caused by fatty liver disease. NASH can lead to permanent scarring and hardening (cirrhosis), and increased risk of liver transplant, liver failure, and hepatocellular carcinoma (HCC). Risk factors include obesity, hyperlipidemia, hypercholesterolemia, diabetes, and hypertension. Obesity in the U.S. has doubled in the last decade alongside a steady rise in fatty liver disease – a silent disease – though patients may start to show signs when it has progressed to NASH. NASH may be reversible with lifestyle changes and clinical trials are also in development.This model showcases the progression of fatty liver to NASH, cirrhosis, and HCC in a series of slices for use in the recruitment of clinical trial candidates for a drug in development to treat NASH. Each liver slice represents a stage, with progression moving left (normal) to right (HCC). The slices include visual and tactile changes that reflect the stage. The fatty liver slice is enlarged and soft, then slices become firmer to represent increased inflammation and fibrosis. Nodules are embedded in the cirrhotic slice. During consultations, the model not only shows progression, but can also be used to demonstrate that damage may be reversible at the NASH slice with treatment. The model provides tangible support to the conversation, with the goal of setting the patient on the right track to improve their health, quality of life, and reduce disease burden.