2022 AMI Online Salon

Project Detail

  • Entrant Name:  Kristen Browne
  • Client: NIAID
  • Copyright: NIAID, 2021
  • Medium/software used: 3D Slicer, ZBrush, Cinema4D and Babylon.JS
  • Final presentation format: Web
  • Primary Audience: Clinicians and Researchers

Project Description

Tuberculosis is a contagious infection that is the 13th leading cause of death and is second only to COVID-19 in deaths from an infectious disease.  95% of cases are in developing countries.  TB-in-3D is a web-based application that was designed to accompany TB Portals, an open-access set of tools and resources that includes CTs and X-Rays from tuberculosis patients around the world.  The 3D interactive provides a unique way for clinicians to visualize, interact with, and explore the progression of this disease in response to varied treatments (or lack thereof) and to discuss it with their students.  They can also use this tool to show patients the dire consequences of failure to comply with complete treatment regimens.  Due to the cost and length of tuberculosis treatment, this failure to comply is a primary reason this curable and preventable disease killed 1.5 million people in 2020. Finally, in certain cases, alongside researchers, we are able to demonstrate features that might impact guidelines used by global institutions like the WHO which dictate how/when a patient is diagnosed or cured of the disease.  The 3D models were segmented directly from CT data using 3D Slicer, then optimized using ZBrush.  The web-based application was built using Babylon.js.  A combination of high contrast color, transparency, and toggles are used to solve the complex problem of visualizing highly complex, nested, 3D objects inside of an organ. Accessible controls are available.