2022 AMI Online Salon

Targeted T cells

Project Details

  • Entrant Name:  Chris Bickel
  • Client: AAAS/Science
  • Copyright: AAAS, 2022
  • Medium/software used: Cinema 4D, Photoshop
  • Final presentation format: Printed journal cover and online issue
  • Primary Audience: Readers of Science

Project Description

Fibrosis affects millions of people with cardiac disease which results in excessive extracellular matrix protein deposition by activated cardiac fibroblasts. This is a hallmark of heart disease and plays a critical role in disease progression to heart failure.Lipid nanoparticles (gold spheres) use antibodies against the CD5 protein (antibodies, blue; CD5, red) to specifically target T cells while inside the bloodstream and tissues with mRNA (light yellow within the nanoparticles). The nanoparticles deliver mRNA to T cells, reprogramming them in vivo to transiently express chimeric antigen receptors (gold) that target pathogenic cardiac fibroblasts. Lipid nanoparticles are initially injected into the circulatory system, so a post injection blood vessel was set to be the scene. I decided that it would be best to focus on the interaction and interface between the lipid nanoparticles and a targeted T cell’s membrane vs adding yet another element of much larger scale that screamed “cardiac”. Juxtaposing many elements of varying sizes and scales within a single piece can be overwhelming, both visually and contextually. That was avoided here and the important size relationship between the T cells and nanoparticles is clear.