2022 AMI Online Salon

SARS-CoV-2 T-cell epitopes derived from in and out-of-frame open reading frames

Project Details

  • Entrant Name:  Su Min Suh
  • Other Contributors Vivian Yeung
  • Client: Broad Institute
  • Copyright: © SciStories LLC, 2021
  • Medium/software used: Adobe Illustrator and Photoshop
  • Final presentation format: Journal Cover
  • Primary Audience: Scientific Audience

Project Description

T cell-mediated immunity plays an important role in controlling SARS-CoV-2 infection, but the repertoire of naturally processed and presented viral epitopes remains uncharacterized. In this issue, Weingarten-Gabbay et al. (3962–3980) found viral epitopes derived from out-of-frame open reading frames (ORFs) in the SARS-CoV-2 genome that elicit T cell responses. The cover image is a metaphor of a picture frame in a gallery. It depicts SARS-CoV-2 T cell epitopes derived from in-frame (canonical) and out-of-frame ORFs as flowers either inside or outside the gold frame, respectively. The HLA-I complexes are represented by purple flowers and the sequences of presented peptides from in-frame and out-of-frame ORFs are indicated in the pistil. The birds illustrate T cells interacting with HLA-I-presented peptides from either in frame or out-of-frame ORFs and are colored according to TCR structure. The gallery wallpaper illustrates that this study occurred in the context of SARS-CoV-2 infection.