2022 AMI Online Salon

Project Details

  • Entrant Name:  Audra Geras
  • Client: Trillium Therapeutics
  • Copyright: Audra Geras, 2022
  • Medium/software used: ZBrush, XSI, Keyshot, Photoshop
  • Final presentation format: Print, web, exhibit panel
  • Primary Audience: Kidney care specialists

Project Description

The purpose of this multi-use, 3D illustration was to depict the detailed structure of the basic filtration units of the kidneys, the glomeruli.  It was designed for kidney care specialists at all levels. The challenge was to create an immersive, atmospheric and dramatic window into the environment of the kidney glomeruli. The illustration incorporates a dramatic magnified view of one of the glomeruli to clearly show the spherical cluster of convoluted, looping capillaries, which form the core of a glomerulus. These capillaries are covered by an interdigitating layer of podocyte cells. The entire spherical mass is enclosed within the Bowman’s capsule. Waste derived from the blood stream is excreted from the capillaries, passes through filtration slits between the podocyte ‘fingers’ and into the glomerular space within the capsule. The urine droplets then coalesce and leave the glomerulus via the proximal tubule.Knowing about the normal, healthy glomerulus is foundational to an understanding of glomerular disease conditions. According to the National Kidney Foundation, ~15% of adults in the US have kidney disease, most commonly diabetic nephropathy. African Americans, Hispanics, American Indians and other minority groups are at higher risk of glomerular disease due to higher rates of diabetes, hypertension and obesity. Women are also at slightly higher risk than men. Unfortunately, 2 out of  5 people with kidney disease are unaware that they have a problem.