2022 AMI Online Salon

Quality Control of Gene Expression Provides Balance to the Cell

Project Details

  • Entrant Name:  Timothy Phelps
  • Client: Jeff Coller, Ph.D., Bloomberg Distinguished Professor of RNA Biology and Therapeutics  Johns Hopkins University
  • Copyright: Tim Phelps, 2022
  • Medium/software used: Pen and ink and photoshop
  • Final presentation format: Journal Cover
  • Primary Audience: Basis science researchers, scientists in molecular and cellular biology

Project Description

To illustrate in summary and eye-catching novel form the major molecular components involved in cellular balance and stability portrayed by intertwined ribosomes, tRNAs, protein chains, mRNA strands, and alpha helix ribbon polypeptides involved in the quality control of gene expression for a journal cover for Molecular Cell. Quality control of gene expression provides balance to the cell. For example, messenger RNA translation and stability are intertwined as described by Bae and Coller. Messenger RNA (mRNA) translation by the ribosome represents the final step of a complicated molecular dance from DNA to protein. Although classically considered a decipherer that translates a 64-word genetic code into a proteome of astonishing complexity, the ribosome can also shape the transcriptome by controlling mRNA stability. An artistic representation of the interconnectivity between gene expression events is depicted in mandala form. “Mandala” is Sanskrit for “circle” and is thought to be a visual metaphor for stability, symmetry, and balance. Key elements of this mandala are a symbolic collection of ribosomes, tRNAs, protein chains, mRNA strands, and alpha helix ribbon polypeptides. All these elements synchronize to impact quality control of gene expression.