2022 AMI Online Salon

Protein Fitness Landscapes and Directed Evolution

Project Detail

  • Entrant Name:  Sydney Agger
  • Client: Phillip Romero, BSE, PhD, Department of Biochemistry, University of Wisconsin-Madison
  • Copyright:  Sydney Agger, 2021
  • Medium/software used: Autodesk 3D Studio Max, VRay, Visual Molecular Dynamics, Adobe Photoshop, Adobe Illustrator, Adobe After Effects, and Adobe Audition
  • Final presentation format: Animation for website and presentations
  • Primary Audience: Undergraduate and Graduate level students

Project Description

Protein fitness landscapes and directed evolution are fundamental concepts that underpin the field of protein engineering. Although the concepts themselves are highly dimensional, they are often introduced to students using multiple 2D representations rendered from data visualization software. These representations can be strung together to describe the relationship between concepts, but many students have difficulty converting the disjointed visuals into a comprehensive story. This animation was created to help instructors explain these elegant concepts, and their underlying components, in a continuous and cohesive story that captures attention and inspires exploration.