2022 AMI Online Salon

Photobiomodulation: Mechanisms of Action

Project Detail

  • Entrant Name:  Sonya Amin
  • Client: LumiThera
  • Copyright: LumiThera, Inc., 2021
  • Medium/software used: Autodesk Maya, Redshift, Adobe AfterEffects, Phtotoshop and Illustrator
  • Final presentation format: HD video
  • Primary Audience: Retinal specialists

Project Description

Photobiomodulation (PBM) therapy is gaining recognition in its application to many diseases, including those affecting the retina. However, broader acceptance by retinal specialists is hampered by skepticism. The prospect that light can stimulate a cellular response with significant therapeutic benefits seems too good to be true and patients may miss out on a potentially life-altering therapy. AXS approached this animation as we would any data-driven mechanism of action video, but with light as the therapeutic. Based on published peer-reviewed findings, our 3D artists and content experts determined how specific wavelengths of PBM light stimulate metabolic pathways. The animation follows PBM light as it enters the eye, illuminating the viewer’s journey through the structures and cells. Within photoreceptors, PBM light activates the mitochondrial cytochrome c oxidase (CcO) pathway, directly stimulating the production of mitochondrial energy in dysfunctional retinal cells.