2022 AMI Online Salon

Migraine: Prostaglandins as Disease Mechanism and Drug Target

Project Details

  • Entrant Name:  Danielle George
  • Client: Rochester Institute of Technology
  • Copyright:  Danielle George, 2022
  • Medium/software used: Photoshop, InDesign, Chimera
  • Final presentation format: PDF print
  • Primary Audience: General Adult Public

Project Description

The goal was to create an educational and visually appealing small poster of an individual suffering from a migraine and depict the conversion of arachidonic acid to prostaglandins in migraine initiation, as well as how ibuprofen alleviates symptoms by blocking production of prostaglandins. Protein configurations were downloaded from the RCSB protein data bank. Small molecules were downloaded from PubChem. All molecules were rendered in Chimera. Proteins were depicted as surface molecules to emphasize the overall shape of the protein and the shape of the binding pocket in a cross section. Small molecules were depicted as ball and stick models for ease in comparing their structures..A reference photo was taken of an individual who suffers from migraines. She was asked to pose in the position she assumes while experiencing a migraine. The figure is female, as women are diagnosed more often than men.The portrait and poster background were painted in Photoshop, and the composition was compiled in InDesign. The major colors are red indicating pain and blue for relief. The figure is the prominent feature, while the molecules are arranged so that the pathways are read from left to right. The font used (Arial) is dyslexic friendly with tracking in between characters increased for readability. The image was run through Colbis (Color Blind Simulator) to ensure readability.