2022 AMI Online Salon

Dual treatment with Kynurenine Pathway Inhibitors and NAD+ Precursors Synergistically Extends Lifespan in Drosophila

Project Details

  • Entrant Name:  Jennifer Fairman
  • Client: Mariann M. Gabrawy, PhD1, Reyhan Westbrook, PhD1, Austin King1,2, Nick Khosravian1,2, Neeraj Ochaney1,2, Tagide DeCarvalho, PhD2, Jennifer E. Fairman, CMI, FAMI2, Ginger L. Milne, PhD3, Fernando J. Vonhoff, PhD2, Jeremy D. Walston, MD1, Peter M. Abadir, M
  • Copyright: Johns Hopkins University SOM, 2022
  • Medium/software used: Adobe Illustrator
  • Final presentation format: Graphical Abstract
  • Primary Audience: Scientists (Molecular Biologists, Geriatric specialists, and Neurochemists)

Project Description

A simple schematic provides context, summarizing the main findings of a study focused on tryptophan metabolism in developing frailty and aging. By showcasing the methodology (L panel) and results (R panel), this study is visually captured at a single glance. Using 3 Drosophila models (A, B and C), the resulting physical and cognitive decline observed is characterized by the impact of kynurenine pathway dysregulation. Depicted is proof-of-concept evidence for the efficacy of using both KP blockade with NAD+ precursor supplementation as a unique and effective anti-aging therapeutic strategy. The authors believe this study serves a strong rationale for the development of tryptophan metabolism-related interventions that can be readily adapted in humans. While instructional color differentiating each treatment was used here and throughout subsequent figures in the paper, this graphical abstract does not rely on color alone for didactic visual instruction. Use of graphic elements was carefully considered for visual organization, scientific clarity, and accessibility for individuals with impaired vision. High-contrast labels name key metabolites measured; those that exhibited undetectable change are gray. Results are shown using up/down arrows indicating changes detected in metabolite levels. Shapes specify time intervals these data were collected. +/- signs represent performance and lifespan while varied body appearance portrays resulting frailty or robustness of each test group.