2021 AMI Online Salon

Window Chamber Method: A Novel Approach of Cellular Imaging

Project Details

  • Entrant Name:  Su Min Suh
  • Client: Ralph DaCosta
  • Copyright: Su Min Suh, 2020
  • Medium/software used:ZBrush, Maya, After Effects, Premiere Pro
  • Final presentation format:1080p Video
  • Primary Audience:Funding Bodies

Project Description

Acute myeloid leukemia (AML) is a non-solid tumor of the bone marrow. Current leukemia treatments are shown to be a challenge because AML cells sequester into hypoxic bone marrow microenvironments where therapeutics become less effective. A novel platform developed by the DaCosta Lab called the Window Chamber method, allows researchers to track AML cells in vivo in mouse models. The ability to observe leukemic cell behavior in real-time within the ‘living’ bone marrow can provide innovative perspectives into the effect of the treatment and the development of new therapeutics. Therefore, the dissemination of this method is critical to open new avenues for leukemia research, which could aid in advancing previous technological barriers in the field.An educational 3D animation was created to spread awareness of this method while increasing interest for funding bodies. This 3D animation aims to effectively address core concepts while smoothly integrating video footage with 3D animation.