2021 AMI Online Salon

Why TLR3 recognizes only dsRNA?

Project Details

  • Entrant Name:  Alex Nazlidis
  • Client: Isabel Romero Calvo, Evelyn Maizels
  • Copyright: Alex Nazlidis, 2021
  • Medium/software used: VMD, UCSF Chimera, ZBrush, 3ds Max, tyFlow, VRay, After Effects, Photoshop, Illustrator
  • Final presentation format: 48 x 36 Poster
  • Primary Audience: Biomedical professional audience

Project Description

The assignment’s purpose was to create an educational molecular visualization illustration targeting the biomedical professional audience. This poster is about a specific family of Toll-like receptors (TLRs), TLR3. Essentially, the visualization explains why TLR3s localized in endosomes selectively bind viral dsRNA and ignore cellular dsRNAs like miRNAs and tRNA hairpins. By utilizing a cellular environment and crystallized structures of the TLR3-dsRNA complex the viewer is immersed in the educational story and by taking advantage of schematic 2D illustrations the explanation of this scientific phenomenon is provided. The creative challenge was to establish a balance between showing enough contextual and biological information about this molecular phenomenon while keeping it as minimal as possible in respect to the target audience.