2021 AMI Online Salon

Small-molecule-induced polymerization triggers degradation of oncoprotein BCL6

Project Details

  • Entrant Name:  Veronica Falconieri Hays
  • Client: Ebert & Fischer Labs of Dana-Farber Cancer Institute
  • Copyright: Veronica Falconieri Hays, 2020
  • Medium/software used: Cinema4D, Photoshop
  • Final presentation format: Journal cover submission, slide image
  • Primary Audience: Research scientists

Project Description

This illustration highlights the findings of Sabicki M, Yoon H, Koeppel J, et al. Small-molecule-induced polymerization triggers degradation of BCL6. Nature. 2020;588(7836):164-168. In this paper, researchers describe a small molecule (blue) that causes a cancer associated protein, BCL6 (peach), to aggregate in helical filaments, and then be degraded.

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