2020 Online Salon
The Short Giant: Exploring the Multiple Functions of the p53 Disordered C-terminal Domain
Project Details
- Entrant Name: Chloe Ma
- Membership Type: Student Submission
- Address: Mississauga, Ontario Canada
- Client: Faculty advisor: Derek Ng
- Copyright: 2020 Chloe (Xiaoyi) Ma
- Medium/software used: Photoshop, Illustrator, Chimera, and Cinema4D
- Final presentation format: Print, two-page magazine spread for a popular science magazine (e.g., Scientific American)
- Primary Audience: Educated lay audience
Project Description
I created this two-page illustration for a popular science magazine in order to visualize at the molecular level: (1) how the disordered C-terminal domain (CTD) of the tumor-suppressor protein p53 interacts with DNA in response to cellular stress; and (2) how post-translational modifications regulate this interaction. I integrated both 3D renderings of p53 alongside more 2D schematic representations in order to visually communicate the molecular functions of this protein in the context of its atomic structure.
