2020 Online Salon
Shugoshin facilitates heat shock transcription
Project Details
- Entrant Name: Sigrid Knemeyer
- Membership Type: Professional Submission
- Other Contributors: Sigrid Knemeyer
- Address: Southborough, Massachusetts USA
- Client: EMBO Journal
- Copyright: 2019 SciStories LLC
- Medium/software used: Photoshop
- Final presentation format: Print
- Primary Audience: Scientists
Project Description
The cover highlights the article on the pericentromeric protein shugoshin 2 (SOG2) by Ryosuke Takii, Akira Nakai and colleagues. The pericentromeric adapter protein shugoshin 2 acts as unexpected HSF1 co-factor and facilitator of RNA Pol II recruitment under heat shock conditions. HSF1 regulates proteostasis capacity in both unstressed and stressed cells, inhibiting progression of age-related diseases including neurodegenerative disease and cancer. SOG1 in association with HSF1 supports cell survival.
