2020 Online Salon
A Visual Model for SARS CoV-2 Membrane Fusion
- Company/Institution: Digizyme Inc.
- Submission Type: Company/Corporation Submission
- Other Contributors: Jonathan Khao, Geoffrey Cheung, Jeannie Park, Gael McGill
- Address: Brookline, Massachusetts USA
- Client: internal project
- Copyright: 2020 Digizyme Inc.
- Medium/software used: Autodesk Maya, Digizyme Molecular Maya, Adobe After Effects
- Final presentation format: Educational Web Animation
- Primary Audience: General Public
Although a great variety of beautiful and accurate depictions of the SARS CoV-2 coronavirus have been created in recent months, many are static images that do not reveal the complex dynamics the virus uses to enter cells. Our visual model integrates numerous structural and dynamic datasets to reveal how the conformational changes of the SARS CoV-2 Spike protein drive membrane fusion. To achieve scientifically-accurate, full-length protein structures and represent their dynamics, we have combined recently-published SARS CoV-2 data with relevant data sets from other betacoronaviruses and viral families that share similar membrane fusion mechanisms (i.e. Influenza and HIV among others). Our goal is to share with a broad audience the breathtaking molecular choreography that allows CoV-2 not only to avoid immune system detection but also to breach the host cell membrane.