2019 AMI Online Salon

The Cancer Paradox

Project Details

  • Entrant Name: Avesta Rastan

  • Membership Type: Student Submission

  • Other Contributors:                         

  • Address: Toronto, Canada

  • Client: Faculty Advisor: Derek Ng

  • Medium/software used: Cinema4D, Chimera, Photoshop, Illustrator, Maya

  • Final presentation format: Print, 2-page spread for a popular science magazine (e.g. Scientific American)

  • Primary Audience: Educated lay audience

Project Description

Cancer is responsible for just under a third of all deaths worldwide. Tumor suppressor p53 is a protein that plays an important role in preventing cells from becoming cancerous. Amino acid mutations in p53 is observed in over 50% of human cancers. Understanding how these critical mutations affect p53 function may be a key in unlocking future cancer therapeutics. I created this two-page spread for a popular science magazine, such as Scientific American, to educate a lay audience on the structure-function relationship between p53 and its role in preventing cancer. This illustration depicts the p53 molecular architecture, mechanism of action, and effect of amino acid sidechain shape and charge on its ability to bind and repair DNA.  A combination of color-coding, negative space, transparent overlays, and callouts were used to enhance the illustration’s communication clarity.