2019 AMI Online Salon

Insulin Signaling Pathway

Project Detail

  • Company/Institution: Harvard Medical School, HMX

  • Entrant Name: Joanne Müller, MA, CMI, FAMI

  • Membership Type: Company/Corporation Submission

  • Other Contributors: Dorothy Fatunmbi, MS, Kate McDonnell-Dowling, PhD, Jess Ahearn, Matthew Gelineau, M.Ed, Michael J.Parker, MD             

  • Address: Boston,MA

  • Client: In-House Project: Harvard Medical School, Office of Online Learning, HMX

  • Medium/software used: Adobe Illustrator, Adobe After Effects, Adobe Premiere

  • Final presentation format:Video in a course on our online learning platform

  • Primary Audience: Pre-health care and health care individuals learning medical topics online

Project Description

This animation depicts an insulin signaling pathway and provides a specific example of a drug–receptor interaction and the subsequent physiological and therapeutic effects. This animation is integrated into 2 courses: depicting the process by which the glucose transporter (GLUT4) is recruited to the cell membrane is important in HMX Biochemistry; explaining insulin’s role in glucose uptake by depicting key steps in that signaling cascade is important for the HMX Pharmacology course.

Though insulin initiates a myriad of signaling cascades, we chose to focus on the pathways relating to glucose uptake. Substrates and proteins were displayed schematically, and extraneous pathways were simplified to maintain clarity and focus. The principles of multimedia learning were implemented, and visuals and sound were tailored to direct focus and enhance didactic storytelling. We have given context to the teaching with brief references to the role of insulin and its relevant impact on human health.