2019 AMI Online Salon

Genesis of high-grade serous carcinoma from fallopian tube cell populations

Project Details

  • Company/Institution: Johns Hopkins University School of Medicine
  • Entrant Name: Lydia Gregg
  • Membership Type: Professional Submission 
  • Address: Baltimore, MD
  • Client: Dr. le-Ming Shih
  • Medium/software used: Zbrush, Cinema 4D, Photoshop
  • Final presentation format: Figure within editorial review article and journal cover image
  • Primary Audience: Gynecological Pathologists

Project Description

This illustration is intended to offer a dramatic editorial depiction of the evolution of high-grade serous carcinoma (HGSC) from fallopian tube cells. The main image depicts the gross appearance of HGSC from a medial view of the right fallopian tube and ovary. Cell populations with a p53 mutational signature are colored blue while serous tubal intraepithelial carcinoma (STIC) and HGSC are yellow. HGSC represents the same cell population as STIC except it has become invasive, moving from the fimbriae of the fallopian tube to the ovary and peritoneal cavity wall. The 3 insets convey (1) the organized appearance of p53 signature cells, which are shown evolving into (2) STIC, with disorganized growth and lymphocytes. STIC has extensive mutations and is depicted migrating from the fallopian tube to form invasive (3) HGSC, shown with an infiltrative appearance and numerous lymphocytes. Not all p53 signature and STIC cell populations on the fimbriae continue to evolve to HGSC.