2018 AMI Online Salon

The HDL Gold Nanoparticle and a Potential Therapy in B cell Lymphoma

Project Details

  • Artist(s):  Stephanie O’Neil
  • Contributors: Angela Gao  ; Novi, Michigan
  • Client: Dr. C. Shad Thaxton
  • Copyright: © 2018 Stephanie O’Neil and Angela Gao
  • Medium / software used: VMD, 3ds Max, ZBrush, Redshift, V-Ray, After Effects
  • Final presentation format: 1920×1080 HD digital display
  • Primary audience: Medical students, physicians, research scientists

Project Description

This animation describes the structure and mechanism of action of a unique nanoparticle, the HDL gold nanoparticle. It closely mimics native high density lipoprotein (HDL) to specifically target and kill lymphoma cells. The purpose of this animation is to teach an academic audience, primarily medical students, physicians, and research scientists, how the HDL gold nanoparticle was created and how its ability to mimic native HDL allows for a completely novel approach to lymphoma treatment.

This piece was created by Stephanie O’Neil and Angela Gao in collaboration with Dr. C. Shad Thaxton at Northwestern University. It takes special consideration in highlighting the important structures which move and interact to form the molecular basis of the mechanism of action.