2018 AMI Online Salon

Ionis-HTTRx: A novel Huntingtin-lowering technique

Project Details

  • Entrant’s name:  Dani Bergey; Chicago, Illinois
  • Client: University of Illinois at Chicago
  • Copyright: © 2018 Dani Bergey
  • Medium / software used: Autodesk 3ds Max, Adobe Photoshop, Adobe Illustrator
  • Final presentation format: Print ad
  • Primary audience: Huntington’s disease community (scientists, patients, families, etc.)

Project Description

The Huntington’s disease (HD) community of patients, family members, researchers, and physicians has been waiting in anticipation for one of several potential therapies to succeed in clinical trials. This print ad describes one of the drugs at the forefront of these efforts, Ionis-HTTRx. Considering that HD patients and their families may be familiar with the name of this drug but not the science behind it, the purpose of this poster is to attract attention to and explain the molecular mechanism of Ionis-HTTRx, and encourage participation in the study. This class assignment required creating a 3D illustration with a focus on lighting, design, and overall composition. I created a sense of molecular scale by using a narrow depth of field and backlights. Accuracy was also a priority: the Ionis-HTTRx antisense oligonucleotide (ASO) is the correct number of base pairs, and I included an RNA hairpin downstream of the ASO binding site to depict the known hairpins in CAG repeat regions.