2018 AMI Online Salon

Gross and Histological Appearance of Endometriotic Lesions

Project Details

  • Artist(s):  Lydia Gregg; Ellicott City, Maryland
  • Client: Johns Hopkins University School of Medicine
  • Copyright: © 2017 Johns Hopkins University
  • Medium / software used: Adobe Photoshop, Cinema 4D, Zbrush
  • Final presentation format: Figure within editorial review article and journal cover image
  • Primary audience: Pathologists

Project Description

This illustration is intended to offer a dramatic editorial depiction of the gross-level and histological appearance of endometriotic lesions in the pelvic cavity. The main image on the left highlights the appearance of an ovarian endometriotic cyst, deep infiltrating endometriosis in the muscular layers of the rectum and bladder, and superficial endometriosis on the surface of the peritoneal cavity, including dense adhesions that have occluded the right fallopian tube. The two insets on the right illustrate the histological contrast between highly-organized normal eutopic endometrium and disorganized endometriotic tissue. The endometriosis inset also shows the presence of old hemorrhage trapped in the lesion and includes a secondary inset depicting the hypothesis of circulating endothelial progenitor cell recruitment to the lesion via a capillary, which is thought to help establish deep infiltrating endometriosis.