2018 AMI Online Salon

CRISPR-Cas9: Mechanism & Applications

Project Detail

  • Artist(s):  Fabian de Kok-Mercado
  • Contributors: Fabian de Kok-Mercado, Laura Bonetta, Stephanie Lepage, Julian Kirk-Elleker, Joyce Hui, Man-San Ma, David Tran, Brendan Polley, Sonya Amin, Neil Losin, Nate Dappen,  ; Chevy Chase, Maryland
  • Client: HHMI
  • Copyright: © 2018 HHMI
  • Medium / software used: Autodesk Maya, Maxon Cinema 4D, Adobe Illustrator, Adobe Photoshop, Adobe After Effects, HTML5
  • Final presentation format: Web based interactive (desktop and mobile)
  • Primary audience: High school and undergraduate science educators and students

Project Description

This interactive allows high school and undergraduate students and science educators to explore the structure and function of the CRISPR Cas9-guide RNA complex and its interactions with DNA, learn about DNA repair mechanisms, and view a series of videos on applications of CRISPR with a diverse group of scientists that use this revolutionary tool. The interactive includes a dynamic and responsive self-paced scrolling molecular animation that divides CRISPR actions into distinct didactic stages: targeting, binding, cleaving, and DNA repair. The interactive is designed to accompany curricula for courses ranging from first-year high school biology, to undergraduate introductory biology, and various upper-level molecular biology and biotechnology courses. Students can explore information in a variety of formats such as cross-sectional views of the molecules with detailed descriptions of function and short summaries of the research studies linked to scientific papers.