2018 AMI Online Salon

Biology and Pharmacology of GABAergic Signaling

Project Detail

  • Artist(s):  Will McAbee
  • Contributors: Kristin Butters, Kristin Traniello, Courtney Sadusky, Thomas Amari, Dave Taylor, Connie Orcutt, Dawn Phelan, John Shea, Joyce Scriver, Christina Wallace, Shauna Leva, Eric Georgette; Belmont, Massachusetts
  • Client: Custom Learning Designs, Inc.
  • Copyright: © 2018 Custom Learning Designs, Inc.
  • Medium / software used: HTML5, Adobe Photoshop, Adobe After Effects, Adobe Illustrator, Maxon Cinema 4D
  • Final presentation format: Web Application
  • Primary audience: Medical Scientist Liaison Teams and Pharmaceutical Sales Representatives

Project Description

In order to speak knowledgably about allopregnanolone, learners must first have a solid understanding of its target, the GABAA receptor. This module explores the role of GABA receptors in the neurophysiology of the central nervous system. The goal of this module is to provide learners with a solid foundation with which to understand how allopregnanolone interacts with the GABAA receptor. Understanding how allopregnanolone affects GABAA receptors first requires an understanding of the basic physiology of how neurons transmit electrochemical impulses, the mechanism of action of GABA, the major neurotransmitter in the central nervous system, an overview of the neurological and psychiatric disorders derived from dysfunctional GABA signaling, and an introduction to the GABA receptor agonists and antagonists which are used to treat these disorders.