2018 AMI Online Salon

ATR-inhibitor: A Novel Approach to Targeting the Achilles’ Heel of Cancer

Project Details

  • Artist(s):  Felix Donghwi Son; Mississauga, Ontario
  • Client: Faculty Advisor: Derek Ng
  • Copyright: © 2018 Felix Donghwi Son
  • Medium / software used: Chimera, Maxon Cinema4D, Adobe Photoshop, and Adobe Illustrator
  • Final presentation format: Print, Journal
  • Primary audience: Educated Lay Audience

Project Description

DNA-damaging agents are a cornerstone of cancer treatment. However, their effectiveness is limited by the DNA-damage response in cancer cells. ATR, a protein kinase, is a critical regulator of this DNA repair pathway and is a novel therapeutic target for drug design. I created this two-page spread for a popular science magazine to illustrate the mechanism of action for VX-970, an ATR-inhibitor and cancer suppressor. I summarized ATR suppression into five steps showing the mechanism at both microscopic and molecular levels. A combination of colour-coding scheme, depth of field, and simplicity in background design were used to enhance communication clarity.

Explore more of the 2017 AMI Salon:

Tomorrow’s Perfect Humans
Resurrecting an Ancient Bite: Virtual Chewing Model Sheds Light on one of the Earliest Primates
An interactive platform to enhance knowledge and understanding of ovarian neoplasms: A pilot program to standardize clerkship education
POND Brain: An e-Learning Resource to Improve Public Understanding of Neurodevelopmental Disorders
Opsonization
Neural Crest Cells & Neuroblastoma
Exercise & the Gut Microbiota
J-Pouch Surgery for Patient Education
Stem Cell Orchestra: Building a Cardiac Patch
The HDL Gold Nanoparticle and a Potential Therapy in B cell Lymphoma
The Dikika Child: Implications for Functional Foot Anatomy
The Case of Ken Lowery
Cancer cells are like weeds: using visual analogies to explain cancer treatment options
Visual Communication Strategies for Study Participant Recruitment: “What is Drugs in Lactation Analysis Consortium (DLAC)?”
Antibiotics & You
Axon Guidance
Adoptive Cell Transfer: A New Type of Cancer Immunotherapy
Michaelis-Menten Dynamics
Macrophages: Heterogeneity, Health, & Disease
Medical Genomics: from Research to Patient Care
The Intersection Between Obesity and Mental Health
How a Bruise Forms
transPLANTS: An Animated Guide to Renal Transplantation
The SNARE Mechanism in the Endomembrane System
Project Ikaros
Your Journey Through ADHD
Myocardial Infarction: The Role of Anti-Platelet Aggregation Treatment
Ahmed Glaucoma Valve: Concept for Trade Show Booth Display
Lap Band System
Ionis-HTTRx: A novel Huntingtin-lowering technique
Types of Skin Cancer
Beyond Consent
CRISPR-Cas9, the new frontier of genome editing
The National Institutes of Health program: All of Us
Weighing the Risks of Egg Retrieval
Scientific American Mock Cover for Social Media Issue
Fantasy Cure
The Small Decision-Maker
Pigeons as Pathologists?
Who funds the research? Problems of the Individual Funder
Future Implications of Using CRISPR-CAS9
Difficulty Knowing When Beliefs Are Unrealistic and Whether Unrealistic Beliefs Are Bad
Precision Medicine and Big Data
Automated Robotic Surgery
Sea Sparkle Cell
Malaria in the United States
Ladybugs & Satellite Design: Folding for Outer Space
Piecing Together Ancient Migration
Modern Robotic Surgery
Microbiota Mission: Fecal microbiota transplant
Molecular Process of Tooth Decay
Atolla Jellyfish
Conformational changes of the CFTR channel
ATR-inhibitor: A Novel Approach to Targeting the Achilles’ Heel of Cancer
Quantification of Cellular Organelle Size
Blood squirting mechanisms of the Texas horned lizard
Mesmerizing Camouflage of the Mirror Spider
Foxglove Toxicity and Medical Applications
What Makes Rainbow Boas Reflect the Rainbow?
Syrinx Musculature Compared in Oscine vs Suboscine Passerines
Pompom Crab
Tick-Borne Encephalitis Virus Neutralization
The New Zealand Pea Crab
Vision of Peacock Mantis Shrimp
Digestive Anatomy of C. didactylus
Alatinidae Box Jellyfish: Known Life Stages and Anatomy
Life Cycle of the Periodical Cicada
Lionfish Invasion Call to Action
Tiny Gold Nanoparticle: A comic about Nanomedicine
Defense Mechanism of the Iberian Ribbed Newt
Punch Mechanism of the Peacock Mantis Shrimp
Advances in Neuromedicine: Venom of the Israeli Death Stalker Scorpion
Nectar and Pollen Gathering of Bumblebees
The Pharyngeal Jaws of the Moray Eel
Camouflage of the Common Octopus
The Integumentary System
Robot Assisted Left Partial Nephrectomy
Vitrectomy with an Epiretinal Membrane Peel
Right Upper Lobe Anterior Segmentectomy
Blepharoplasty and Levator Resection
Phacoemulsification with Intraocular Lens Implantation
Endoscopic Dacryocystorhinostomy
Pig Ovariohysterectomy
Arthrodesis of the First Metatarsophalangeal Joint
Aqueous Shunt Implantation
Total Parotidectomy
Cesarean Section Surgical Illustration
T10 to L3 Scoliotic Spinal Fusion
Laparoscopic-assisted Right Hemicolectomy
The Neuroanatomy of the Spinal Cord
Ventral-lateral View of The Brain
Facial Feminization Surgery
Intraoperative Floppy Iris Syndrome (IFIS) During Cataract Surgery
Sylvia Robinson v. State Farm
Acute Chest Syndrome
Medical Legal Illustrations for the Plaintiff
Chronic Obstructive Pulmonary Disease
Pulmonary Embolism
Cranial nerves within the cavernous sinus
Tooth Decay
The Female Reproductive System
Squamous Cell Carcinoma of the Cervix
Hypospadias
Autosomal Dominant Polycystic Kidney Disease: Etiology and Pathogenesis
Diabetic Retinopathy
Etiology and Pathogenesis of Kidney Stone Disease
Safe Lifting Posture
Pulmonary Tuberculosis
False Alarm: Having a Panic Attack
Cystic Fibrosis
Anatomy of the Cochlear Nerve
Osteosarcoma
Pelvic Cavity
The Muscular Layers of the Foot
Pneumococcal Meningitis
Pathophysiology of Primary Spontaneous Pneumothorax
Conceptualizing Sequential Events for Medical Malpractice Visualization
Vasculature of the Testes
Anatomy of the Infratemporal Fossa
Pathology of Acne Vulgaris
Pathology of Oral Herpes
Functional Anatomy of the Pancreas
Muscles and Retinacula of the Foot
Titan Demonstration Model
Progression of Autosomal Dominant Polycystic Kidney Disease Over Time
Hologic 5-Day Targeted Therapy Breast Model
Equine Phalanges: A Comparison of 3D Capture Methods
Understanding Chronic Immune Thrombocytopenia and Severe Aplastic Anemia
Model Hand with Anthrax Lesions and Eschars
Laparoscopic Myomectomy Simulator
Understanding Heartworm Disease
Anatomy and Diagnostic Imaging of the Equine Paranasal Sinuses
Ultrasound of the Equine Stifle
Extremities Alive! The Upper Extremity: The Wrist – An Interactive Approach to Joint Movement and Muscle Function
Introduction to Human Anatomy iBook
Midwifery Enhanced e-Textbook
Murmur Spree
Guardians of the Genome
Biology and Pharmacology of GABAergic Signaling
Exhibit booth for Eisai at the ASCO 2018 Annual Meeting
Simulated Vision Impairment
Osso VR: Tibial Nail Medical Device Simulation
Basic Science Breakthroughs: Fragile X Syndrome
E-Guide for Physical Diagnosis – the Pelvic and Breast Exam
Pro-Consult Application Series: The OT Kinesiology Pro Consult & Musculoskeletal Pro-Consult
CPX Calc.
Representations of DNA
Digital Injury Summary of Jane Doe
CRISPR-Cas9: Mechanism & Applications
Central Dogma and Genetic Medicine
Right ankle fracture surgery – John Doe
Cinematic Summary of Injuries: Gunshot
The Science of a Snowflake
Ellex- ABiC with iTrack
How STELARA Works in Crohn’s Disease
Understanding ADPKD
YONDELIS®: A Guide to Your 24-Hour Outpatient Infusion Experience
ARTAS Patient Education Video
Personalized Cancer Vaccine
Xytex Presents: Specimen Collection and Processing
Anabasum: Mechanism of Action
Immunotherapy
Hepatic Artery Aneurysm – Resection and Hepatic Artery Reconstruction
Cholesterol Good and Bad
Antibiotics vs. Bacteria: Fighting the Resistance
NGF Metabolism in Alzheimer’s Disease
Animations created for The Gene Doctors
Overview of Pharmacokinetics—Metabolism and Excretion
The Science of Malaria
Screening for Colorectal Cancer
Atrial Septal Defect
Stereoelectroencephalography (SEEG)
Research Information Center-Center for Biomedical Discovery
Norwood Procedure for Hypoplastic Left Heart Syndrome
Brain & Behavior: An Introduction to Behavioral Neuroscience
Lateral Skull Base Surgery. The House Clinic Atlas
Endoscopic Sinonasal Dissection Guide, Second Edition
Lymphedema: Complete Medical and Surgical Management. 1st ed.
Mayo Clinic Principles of Shoulder Surgery
Managing Discovery in the Life Sciences: Harnessing Creativity to Drive Biomedical Innovation
Atlas of Minimally Invasive Surgical Operations
Surgical Repair of Comminuted Left Calcaneal Fractures
Left Midfoot Arthrodesis, Part 1 and Part 2
Flame Burn Victim vs. Nissan
Neurovascular Injuries From Improper Footling Breech Delivery Technique
Jonathan Doe’s Right Ear Cholesteatoma and Resulting Surgeries
John Doe’s Prevertebral Hematoma and Resulting Surgery
Orbital Floor Fracture
Right Above the Knee Amputation
John Doe’s Summary of Injuries
Facial Injuries; Removal of Hardware and Placement of PEEK Implants
Injury to left foot – John Smith
Mechanism of injury – Zhang Lee
Staghorn Kidney Stone
Total Penis and Scrotum Transplant
Aortic Valve No Exchange Catheter (AVNEC)
Thyroid Disease
Midface Lift using minimally invasive device
Cancer Immunity Cycle: Botanical Installation
Novartis Pipeline Compounds: Style Guide and Illustrations
JH Department of Environmental Health & Engineering
CRISPR-Cas9 Gene Editing in Bacteria
Hemodynamic Sculpting of the Heart Valves
Lost Ancient Mammals of the Caribbean
Bam, Zap, Kapow: Brain Augmentation With Cognition-Enhancing Drugs
Medical Students Fall Short on Blood Pressure Check Challenge
The Dynamic and Vulnerable Teenage Brain
Eye of the Storm
FP Essentials: Valvular Heart Disease in Adults
Accelerating scientific discovery and translational research at the intersection of chemistry, materials science, engineering, and biomedicine through convergent science.
New Life for HCV-Infected Livers
A landscape of disgust
Gross and Histological Appearance of Endometriotic Lesions
‘Waves of the Future’
Stimulant and Designer Drug Use
Pseudobulbar Affect
Male Contraceptives: Sperm Invaders
T Cells Triggered to Fight Cancer
Condensin motor: A driving force for chromatin organization
Targeting Lassa Virus
Gut Microbes and Cancer
Life Support for Livers
Fertilization
Muscles of the Eustachian Tube
Sapphire Ablation Laser
Cosmetic Injection Techniques
Twin-to-Twin Transfusion Syndrome
Exosome Biology 101
Valve-in-Valve Transcatheter Aortic Valve Replacement (TAVR) for the Management of a Degenerated Bioprosthetic Aortic Root
Pioneering Lymphatic Intervention Techniques
Phimosis in Kittens: Two Surgical Approaches
Maxillary swing and free muscular flap for osteoradionecrosis in nasopharyngeal carcinoma
Tissue Engineered Vascular Grafts
Common Finger Injuries
Novel Reformulation of Valsartan (ARB) for Treatment of Chronic Diabetic Wounds
Deep Brain Stimulation for Treatment for Pediatric Dystonia
Peritorcular Meningioma Resection
Groin Hernia Surgical Repair
Pelvic Organ Prolapse Quantification (POP-Q) Points and Stages
Life reconstruction of the integument of Daspletosaurus horneri, based on the distribution of texture on the facial bones
Transoral Outlet Reduction (TORe) after Gastric Bypass
Hippocampus and Mesolimbic Anatomy
The Tongue Adaptations of the Pangolin
Partial Cholecystectomy
Marginal Branches of the Facial Nerve
Heart Transplantation in Situs Inversus Totalis
Lateral Approaches to the Lumbar Spine: Relevant Surgical Anatomy
Lumbar Interbody Fusions: Anterior, Oblique, & Lateral
Diseases Affecting the Auditory System
Cardiac Anatomy of 22-Month-Old Conjoined Twins with Complex Congenital Heart Disease
The Anatomy of a Mosquito Bite
Cell Envelope Stabilization in Gram-negative Q Fever Bacterium Coxiella burnetii.
Freehand Subaxial Pedicle Screw Placement
Meningitis
When Endometriosis May Cause Back Pain
Three Stage Surgery to Repair Conchal Bowl Defect
Proposed Routes of Bacterial Transmission in utero
Proximal Hamstring Repair
Cochlear Implant
Crafting Arc: The Anatomy of Skiing – Coiling
Fetal conditions treated by UC Davis Fetal Care and Treatment Center
Malignant Pleural Mesothelioma: Staging, Biopsy, and Removal
Bioinspired Slug-Slime Adhesive Patch
Classification of Hip Fracture According to Anatomical Fracture Site and Selected Treatments
The Hepatitis B Virion and Replication CycleTracheal Intubation of the Cat
Tracheal Intubation of the Cat