2018 AMI Online Salon

ATR-inhibitor: A Novel Approach to Targeting the Achilles’ Heel of Cancer

Project Details

  • Artist(s):  Felix Donghwi Son; Mississauga, Ontario
  • Client: Faculty Advisor: Derek Ng
  • Copyright: © 2018 Felix Donghwi Son
  • Medium / software used: Chimera, Maxon Cinema4D, Adobe Photoshop, and Adobe Illustrator
  • Final presentation format: Print, Journal
  • Primary audience: Educated Lay Audience

Project Description

DNA-damaging agents are a cornerstone of cancer treatment. However, their effectiveness is limited by the DNA-damage response in cancer cells. ATR, a protein kinase, is a critical regulator of this DNA repair pathway and is a novel therapeutic target for drug design. I created this two-page spread for a popular science magazine to illustrate the mechanism of action for VX-970, an ATR-inhibitor and cancer suppressor. I summarized ATR suppression into five steps showing the mechanism at both microscopic and molecular levels. A combination of colour-coding scheme, depth of field, and simplicity in background design were used to enhance communication clarity.