X inactivation – Genetics of calico cats

miyamoto_m_16L_animation from AMI on Vimeo.

Category: L Animation

Title of entry: X inactivation – Genetics of calico cats

Entrant’s name: Mao Miyamoto

Membership Type: Student

Other contributors:

Address: Chicago, IL


Medium / software used:

Final presentation format:

Primary audience:

Intended purpose: This animation is made to introduce pre-medical and higher-level college

students majoring biology to X inactivation. X inactivation involves concepts and expertise of

developmental biology, genetics, and molecular biology. Thus, it is an excellent subject to teach

biology comprehensively while it is a challenging topic for students to fully understand. This

animation starts with an introduction that calico cats, the most visible example of x inactivation, are

almost all females. By using a calico cat as the main character, the animation strives to tell the story

in a more engaging way. A 2D animation technique is used to explain the conceptual information

such as set up of sex chromosomes in mammals and genes of fur colors in calico cats while 3D

techniques are used to explain in depth information of the molecular biology. The concept part and

the technical part are brought reciprocally to make the transition smoother and more natural, and to

tell the story more interestingly.